Carol

Record added by Jurg Ott (the original Rockefeller list)

Combined Annotation scoRing toOL

CAROL is a combined functional annotation score of non-synonymous coding variants. A major challenge in interpreting whole-exome data is predicting which of the discovered variants are deleterious or neutral. To address this question in silico, we have developed a score called Combined Annotation scoRing toOL (CAROL),which combines information from two bioinformatics tools: PolyPhen-2 and SIFT, in order to improve the prediction of the effect of non-synonymous coding variants. The combination of annotation tools can help improve automated prediction of whole-genome/exome non-synonymous variant functional consequences.

Eleftheria Zeggini’s group (Wellcome Trust Sanger Institute)

http://www.sanger.ac.uk/resources/software/carol/

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