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Ehp

EHP

Record added by Jurg Ott (the original Rockefeller list)

Full Name

Estimation of Haplotype frequencies from Pooled DNA samples

Description

This program provides variance estimates for haplotype frequency estimates, it allows several kinds of missing information in the genotype data, it also allows for combined genotype data of different pool sizes. This program can be used for testing haplotype-disease associations in case control studies by calculating the likelihood ratio test: 2 log(likelihood for cases) + 2 log(likelihood for controls) - 2 log(likelihood for case+controls).

Author

Yaning Yang (University of Science, Technology, Hefei, Anhui Province, China) (email: ynyang@gmail.com)

Language

R/S-plus

Reference

Y Yang et al. (2003), “Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA”, Proceedings of the National Academy of Sciences , 100(12):7225-7230.

EH