Generecon

Record added by Jurg Ott (the original Rockefeller list)

GeneRecon is a software package for linkage disequilibrium mapping using coalescent theory. It is based on a Bayesian Markov-chain Monte Carlo (MCMC) method for fine-scale linkage-disequilibrium gene mapping using high-density marker maps. GeneRecon explicitly models the genealogy of a sample of the case chromosomes in the vicinity of a disease locus. Given case and control data in the form of genotype or haplotype information, it estimates a number of parameters, most importantly, the disease position.

Thomas Mailund (email: mailund@birc.au.dk) (Univ of Oxford, UK, Univ of Aarhus, Denmark)

http://www.daimi.au.dk/~mailund/GeneRecon/

C++

UNIX, Linux, MacOS, MS-Windows

Mailund, Schierup, Pedersen, Madsen, Hein, Schauser (2006), “GeneRecon – A coalescent based tool for fine-scale association mapping”, Bioinformatics, 22(18):2317-2318.