Hapstat

HAPSTAT

Record added by Jurg Ott (the original Rockefeller list)

Description

HAPSTAT is a user-friendly software interface for the statistical analysis of haplotype-disease association. HAPSTAT allows the user to estimate or test haplotype effects and haplotype-environment interactions by maximizing the (observed-data) likelihood that properly accounts for phase uncertainty and study design. The current version considers cross-sectional, case-control and cohort studies.

Author

Danyu Lin
Donglin Zeng (email: linsoft@bios.unc.edu)

URL

http://www.bios.unc.edu/~lin/hapstat/

OS

MS-Windows(XP/2000/NT/98)

Reference

Lin, Zeng, Millikan (2005), “Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies”, Genetic Epidemiology, 29:299-312.
Lin, Zeng (2006), “Likelihood-based inference on haplotype effects in genetic association studies (with discussion)”, Journal of American Statistical Association, 101:89-118.
Zeng, Lin, Avery, North, Bray (2006), “Efficient semiparametric estimation of haplotype-disease associations in case-cohort and nested case-control studies”, Biostatistics, 7(3):486-502.