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Rc Tdt

RC-TDT

Record added by Jurg Ott (the original Rockefeller list)

Full Name

Reconstruction-Combined Transmission Disequilibrium Test

Version

1.1d (Jul 2006)

Description

A family-based association method that allows testing for linkage in the presence of linkage disequilibrium between an autosomal marker and a disease even if there is only incomplete parental-marker information. Recently, Horvath et al. (2000) described a similar procedure (XRC-TDT) for X-linked markers. The distribution contains SAS macros that calculate the RC-TDT and XRC-TDT test statistics, as well as their respective exact P values.

Author

Michael Knapp (Univ Bonn)

URL

http://www.uni-bonn.de/~umt70e/soft.htm

Language

SAS macro

Reference

  • Knapp (1999), “The transmission/disequilibrium test and parental-genotype reconstruction: the reconstruction-combined transmission/disequilibrium test”, American Journal of Human Genetics, 64(3):861-870
  • Knapp (1999b), “Using exact P values to compare the power between the reconstruction-combined transmission/disequilibrium test and the sib transmission/disequilibrium test” (letter), American Journal of Human Genetics, 65:1208-1210. [ html]
  • Horvath, Laird, Knapp (2000), “The transmission/disequilibrium test and parental-genotype reconstruction for X-chromosomal markers”, American Journal of Human Genetics, 66(3):1161-1167. [ html]